For Alice, he's convincing her that yukkuri is a manju and shouldn't feel pain or heat. It's all just in her mind, she's tricking herself to feel pain. Of course it doesn't work and Alice is still broken.
For Reimu, he's alternating between saying what Reimu eats is sweets sweets and uneasy things (such as Reimu's poo poo or bitter chocolate). It's the same thing (he didn't even touch) and Reimu changed between happyness and suffering from reaction of what she thought she's eating.
Patchouli... probably blown up before he even said a thing.