Yukkuri must have it rough, having mainly a decentralized disgestive system. Food and water are introduced to their innards directly for digestion, and they have no secondary organs to buffer any ill effects. For most things I imagine this isn't much of a problem, mind you, since they seem to be able to effectively process anything including, in some rare cases, inanimate matter, and turn it into the same substance as their innards.
Liquids are probably a pain for yukkuri since they can spread throughout the yukkuri's body, making it harder to be the focus of digestion than solid foods. Alcohol must be a real pain, on the other hand, since they need their digestion to function properly to break down the alcohol at all. The process of distributing their digestion throughout their whole body must be relatively taxing and slow.
Possibly worse, a drunk yukkuri risks severe dehydration (or oversaturation, if they overdo solving their thirst) as their moisture management is much more fickle than other creatures.